HS6ST2-AS1

Across TCGA pan-cancer cohorts, HS6ST2-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HS6ST2-AS1 data layer.

The strongest signal is observed in thymoma (THYM), where higher HS6ST2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HS6ST2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

THYM, KICH, and PAAD are the cancer types where HS6ST2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	II,III,IV	0.177	0.761	<.001	75	view →
KICH	DFS	Tertile	II,III,IV	0.132	0.792	.005	45	view →
PAAD	DFS	Tertile	All	0.167	0.511	.010	36	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
HNSC	OS	Tertile	IV	0.241	0.554	.004	33	view →
LIHC	OS	Tertile	III,IV	0.094	0.615	<.001	27	view →
LGG	OS	Tertile	All	0.955	0.876	.005	21	view →
UCS	OS	Tertile	All	0.312	0.647	.002	18	view →
COAD	DFS	Tertile	III,IV	0.361	0.708	.018	18	view →
SARC	OS	Tertile	All	0.665	0.856	.011	18	view →
KIRC	DFS	Tertile	III,IV	0.879	0.455	.037	12	view →
KIRP	OS	Tertile	All	0.326	0.736	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HS6ST2-AS1–THYM (DFS)

Open the THYM breakdown →