HS6ST1

Across TCGA patient cohorts, HS6ST1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,005 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HS6ST1-associated genes across cancer lineages are PKP4-AS1, HSF4, and ATE1. Each is linked with HS6ST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS6ST1-to-partner and partner-to-HS6ST1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS6ST1 versus PKP4-AS1 in HNSC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS6ST1→partner) and Y-score (partner→HS6ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PKP4-AS1 →	+0.672	+0.425	.003	.004	3	3
OV	HSF4 →	+1.346	+0.789	<.001	.003	3	2
LUAD	ATE1 →	+0.544	+0.408	.006	.005	3	2
OV	CCDC34 →	-0.629	-0.656	<.001	.001	3	2
LSCC	IVNS1ABP →	+0.665	+0.346	<.001	.001	3	2
OV	KLHL29 →	+0.612	+0.637	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,005 associations by consensus.

HS6ST1 vs PKP4-AS1 — HNSC

Explore this scatter interactively →