HS3ST6

Across TCGA pan-cancer cohorts, HS3ST6 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HS3ST6 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HS3ST6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HS3ST6 expression acts as an unfavorable survival marker.

HNSC, UCEC, and LGG are the cancer types where HS3ST6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.078	0.710	<.001	24	view →
UCEC	OS	Median	All	0.725	0.929	.001	16	view →
LGG	OS	Median	All	0.361	0.812	.002	12	view →
PRAD	DFS	Median	All	0.072	0.935	<.001	6	view →
SARC	DFS	Median	All	0.096	0.591	.006	3	view →
SKCM	OS	Median	All	0.595	0.791	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HS3ST6–HNSC (DFS)

Open the HNSC breakdown →