HS3ST6

Across TCGA pan-cancer cohorts, HS3ST6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HS3ST6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HS3ST6 RNA is repressed in tumor relative to normal tissue. In most cancer types HS3ST6 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where HS3ST6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HS3ST6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.884	<.001	11	view →
COAD	Male	II,III,IV	−1.216	<.001	10	view →
KICH	Male	All	−1.890	<.001	9	view →
HNSC	Female	III,IV	−2.114	.004	7	view →
LUAD	Female	III,IV	−1.218	<.001	7	view →
KIRP	Male	All	−0.893	<.001	6	view →
READ	All	All	−0.926	.013	5	view →
THCA	All	All	+0.226	<.001	5	view →
STAD	All	II,III,IV	−1.277	.008	4	view →
BRCA	All	All	+0.237	.029	4	view →
PRAD	All	All	−0.688	<.001	2	view →
CHOL	All	All	+0.541	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HS3ST6–KIRC

Open the KIRC breakdown →