HS3ST6

Across TCGA patient cohorts, HS3ST6 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HS3ST6-associated genes across cancer lineages are Melanocytes, Skeletal muscle, and MPP. Each is linked with HS3ST6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST6-to-partner and partner-to-HS3ST6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanocytes grouped by HS3ST6-low versus HS3ST6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST6→partner) and Y-score (partner→HS3ST6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Melanocytes →	+0.067	+3.195	.016	.009	3	1
SKCM	Skeletal muscle →	+0.052	+1.880	.003	.032	3	1
STAD	MPP →	+0.025	+3.809	.001	.018	3	1
STAD	Osteoblast →	+0.046	+4.254	<.001	.008	3	1
SKCM	Endothelial cells →	-0.041	-2.933	.022	.036	2	1
UCEC	Hepatocytes →	-0.012	-2.978	.043	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Melanocytes by HS3ST6 expression — SKCM

Explore this box plot interactively →