HS3ST6

Across TCGA cell cohorts, HS3ST6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,151 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HS3ST6-associated GO terms across cancer lineages are Regulation of plasminogen activation, Lysosomal lumen acidification, and Nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with HS3ST6 in more than 5 cancer types. Because this analysis shows association rather than direction, both HS3ST6-to-partner and partner-to-HS3ST6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasminogen activation grouped by HS3ST6-low versus HS3ST6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST6→partner) and Y-score (partner→HS3ST6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of plasminogen activation →	-0.184	-0.533	.002	.004	2	6
OESOPHAGUS	Lysosomal lumen acidification →	+0.093	+0.430	.001	.002	3	5
OVARY	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.092	+0.288	<.001	<.001	3	5
OVARY	Pericardium morphogenesis →	+0.879	+0.243	.001	.006	3	5
OESOPHAGUS	Regulation of myoblast fusion →	+0.102	+0.520	.005	.008	3	5
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.121	+0.541	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,151 associations by consensus.

Regulation of plasminogen activation by HS3ST6 expression — SOFT_TISSUE

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