HS3ST4

Across TCGA patient cohorts, HS3ST4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,941 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HS3ST4-associated proteins across cancer lineages are SPTBN1, CTSF, and IPO4. Each is linked with HS3ST4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST4-to-partner and partner-to-HS3ST4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS3ST4 versus SPTBN1 in GBM, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST4→partner) and Y-score (partner→HS3ST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPTBN1 →	+0.459	+0.956	<.001	<.001	3	3
LUAD	CTSF →	+0.444	+0.334	<.001	.008	3	3
GBM	IPO4 →	-0.358	-0.915	<.001	<.001	3	3
BRCA	EPB41L2 →	+0.401	+0.278	<.001	.001	3	3
GBM	INPP1 →	+0.506	+0.944	<.001	<.001	3	2
LSCC	MARK1 →	+0.528	+0.662	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,941 associations by consensus.

HS3ST4 vs SPTBN1 — GBM

Explore this scatter interactively →