HS3ST4

Across TCGA pan-cancer cohorts, HS3ST4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HS3ST4 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HS3ST4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HS3ST4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CHOL show a favorable association.

HNSC, KIRC, and CHOL are the cancer types where HS3ST4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.683	0.499	<.001	133	view →
KIRC	OS	Median	All	0.561	0.715	.001	39	view →
CHOL	DFS	Tertile	All	0.739	0.293	.014	30	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	25	view →
ACC	OS	Quartile	All	0.954	0.473	.005	21	view →
MESO	OS	Quartile	All	0.259	0.833	.006	15	view →
BLCA	DFS	Median	IV	0.094	0.287	.008	14	view →
LAML	DFS	Median	All	0.479	0.651	.010	14	view →
BRCA	DFS	Quartile	All	0.579	0.460	.008	13	view →
PAAD	OS	Tertile	All	0.491	0.338	.023	12	view →
LUAD	DFS	Tertile	IV	0.447	0.790	.025	12	view →
SARC	OS	Quartile	All	0.410	0.737	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HS3ST4–HNSC (DFS)

Open the HNSC breakdown →