HS3ST4

Across TCGA patient cohorts, HS3ST4 mutation is significantly associated with the RNA expression of many other genes, with 2,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST4-associated genes across cancer lineages are MIR6071, KRTAP13-1, and ZNF317P1. Each is linked with HS3ST4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST4-to-partner and partner-to-HS3ST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6071 grouped by HS3ST4-low versus HS3ST4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST4→partner) and Y-score (partner→HS3ST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR6071 →	+0.590	+4.452	<.001	.006	3	3
SCLC	KRTAP13-1 →	+0.098	+4.039	.002	.009	3	2
READ	ZNF317P1 →	+0.094	+5.219	<.001	.006	3	2
READ	RN7SL612P →	+0.340	+5.219	<.001	.006	3	2
UCEC	SLC2A13 →	+0.474	+2.949	.001	<.001	3	2
UCEC	ANKRD9 →	+0.539	+2.917	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,275 associations by consensus.

MIR6071 by HS3ST4 expression — HNSC

Explore this box plot interactively →