HS3ST4

Across TCGA patient cohorts, HS3ST4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST4-associated genes across cancer lineages are Shc_pY317, Caspase-8, and eEF2. Each is linked with HS3ST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST4-to-partner and partner-to-HS3ST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by HS3ST4-low versus HS3ST4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST4→partner) and Y-score (partner→HS3ST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.198	-3.459	.002	.005	3	2
UCEC	Caspase-8 →	-0.269	-3.143	.014	.018	3	2
UCEC	eEF2 →	+0.383	+2.115	.014	.019	3	1
UCEC	EGFR_pY1068 →	-0.244	-2.115	.026	.019	3	1
UCEC	GATA6 →	-0.179	-3.899	.007	<.001	3	1
UCEC	IGFBP2 →	-0.805	-3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Shc_pY317 by HS3ST4 expression — UCEC

Explore this box plot interactively →