HS3ST4

Across TCGA cell cohorts, HS3ST4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,398 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HS3ST4-associated GO terms across cancer lineages are RNA catabolic process, Nucleic acid catabolic process, and Negative regulation of protein catabolic process. Each is linked with HS3ST4 in more than 5 cancer types. Because this analysis shows association rather than direction, both HS3ST4-to-partner and partner-to-HS3ST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA catabolic process grouped by HS3ST4-low versus HS3ST4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST4→partner) and Y-score (partner→HS3ST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA catabolic process →	+0.070	+3.801	<.001	<.001	3	6
BONE	Nucleic acid catabolic process →	+0.059	+3.802	<.001	<.001	3	5
SKIN	Negative regulation of protein catabolic process →	+0.033	+0.013	<.001	.001	3	4
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.173	+3.410	.001	.003	3	4
BONE	Protein processing →	-0.070	-3.462	.002	<.001	3	3
BONE	Ribosome assembly →	+0.077	+3.115	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,398 associations by consensus.

RNA catabolic process by HS3ST4 expression — BONE

Explore this box plot interactively →