HS3ST4

Across TCGA cell cohorts, HS3ST4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HS3ST4-associated genes across cancer lineages are PRAMEF10, PRAMEF17, and PRAMEF25. Each is linked with HS3ST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST4-to-partner and partner-to-HS3ST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by HS3ST4-low versus HS3ST4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST4→partner) and Y-score (partner→HS3ST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF25 →	+0.175	+4.523	<.001	.003	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.022	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PRAMEF10 by HS3ST4 expression — LUNG_SCLC

Explore this box plot interactively →