HS3ST2

Across TCGA patient cohorts, HS3ST2 mutation is significantly associated with the RNA expression of many other genes, with 1,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST2-associated genes across cancer lineages are GNPDA1, ABCC6P2, and ATP5MC3. Each is linked with HS3ST2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST2-to-partner and partner-to-HS3ST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPDA1 grouped by HS3ST2-low versus HS3ST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST2→partner) and Y-score (partner→HS3ST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPDA1 →	+0.523	+3.470	<.001	.002	3	3
UCEC	ABCC6P2 →	-0.439	-2.978	.004	.001	3	3
UCEC	ATP5MC3 →	+0.493	+3.624	.006	.001	3	3
UCEC	FXN →	+0.461	+3.492	.002	.002	3	3
UCEC	STOML2 →	+0.572	+3.847	<.001	<.001	3	3
UCEC	URM1 →	+0.407	+2.708	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,167 associations by consensus.

GNPDA1 by HS3ST2 expression — UCEC

Explore this box plot interactively →