HS3ST2

Across TCGA pan-cancer cohorts, HS3ST2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HS3ST2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HS3ST2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HS3ST2 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where HS3ST2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HS3ST2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.153	<.001	12	view →
KIRP	Male	All	+3.461	<.001	9	view →
LIHC	Male	II,III,IV	+0.935	<.001	7	view →
LUSC	All	II,III,IV	−1.811	<.001	6	view →
KICH	All	All	+0.822	.002	6	view →
STAD	All	II,III,IV	+1.003	<.001	4	view →
PRAD	All	All	+0.483	.002	2	view →
COAD	All	II,III,IV	+0.357	.038	2	view →
THCA	Male	III,IV	−0.547	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HS3ST2–KIRC

Open the KIRC breakdown →