HS3ST2

Across TCGA cell cohorts, HS3ST2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS3ST2-associated genes across cancer lineages are HPGDS, SERPINA12, and COL6A5. Each is linked with HS3ST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST2-to-partner and partner-to-HS3ST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPGDS grouped by HS3ST2-low versus HS3ST2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST2→partner) and Y-score (partner→HS3ST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HPGDS →	+0.063	+3.145	<.001	.004	3	1
SKIN	SERPINA12 →	+0.024	+3.505	<.001	<.001	3	1
SKIN	COL6A5 →	+0.214	+3.938	<.001	<.001	3	1
SKIN	OR13D1 →	+0.023	+3.345	<.001	.001	3	1
SKIN	FGF3 →	+0.041	+3.099	<.001	.002	3	1
SKIN	RBMY1E →	+0.102	+3.240	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

HPGDS by HS3ST2 expression — SKIN

Explore this box plot interactively →