HS3ST1

Across TCGA patient cohorts, HS3ST1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,738 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HS3ST1-associated genes across cancer lineages are HLF, LINC00538, and CDCA5. Each is linked with HS3ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS3ST1 versus HLF in GBM, with a Pearson correlation of -0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HLF →	-1.655	-0.706	.004	.002	3	2
GBM	LINC00538 →	-0.943	-0.996	<.001	.001	3	2
HNSC	CDCA5 →	+0.995	+0.567	.009	.002	3	2
PDAC	CLSPN →	+0.730	+1.251	.003	<.001	3	2
LSCC	KLHL38 →	+0.365	+0.895	.003	<.001	3	2
LSCC	KCNH8 →	-1.068	-0.945	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,738 associations by consensus.

HS3ST1 vs HLF — GBM

Explore this scatter interactively →