HS2ST1

Across TCGA cell cohorts, HS2ST1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HS2ST1-associated genes across cancer lineages are OTOP1, MRGPRX2, and OR4E2. Each is linked with HS2ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS2ST1-to-partner and partner-to-HS2ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOP1 grouped by HS2ST1-low versus HS2ST1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS2ST1→partner) and Y-score (partner→HS2ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OTOP1 →	+0.012	+4.977	<.001	.007	3	1
SKIN	MRGPRX2 →	+0.006	+4.977	<.001	.007	3	1
SKIN	OR4E2 →	+0.015	+4.977	<.001	.007	3	1
SKIN	GUCA2B →	+0.155	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OTOP1 by HS2ST1 expression — SKIN

Explore this box plot interactively →