HS1BP3

Across TCGA pan-cancer cohorts, HS1BP3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HS1BP3 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HS1BP3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HS1BP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, STAD, and UCEC are the cancer types where HS1BP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.159	0.627	.014	42	view →
STAD	OS	Median	IV	0.001	0.544	<.001	15	view →
UCEC	DFS	Median	All	1.000	0.626	.012	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HS1BP3–HNSC (DFS)

Open the HNSC breakdown →