HS1BP3

Across TCGA pan-cancer cohorts, HS1BP3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HS1BP3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HS1BP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HS1BP3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where HS1BP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HS1BP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.177	<.001	12	view →
KIRC	Male	III,IV	+0.897	<.001	11	view →
THCA	All	IV	−0.677	<.001	10	view →
LIHC	Male	II,III,IV	+1.062	<.001	9	view →
KICH	Female	All	−1.066	<.001	7	view →
KIRP	Male	II,III,IV	+0.703	<.001	7	view →
BRCA	All	All	+0.290	<.001	6	view →
BLCA	Male	III,IV	−1.332	<.001	5	view →
COAD	All	All	+0.224	.008	5	view →
CHOL	All	All	+1.464	<.001	3	view →
STAD	Male	III,IV	+0.775	.013	2	view →
UCEC	All	All	−0.255	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HS1BP3–HNSC

Open the HNSC breakdown →