HS1BP3

Across TCGA pan-cancer cohorts, HS1BP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HS1BP3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HS1BP3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HS1BP3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where HS1BP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.676	0.349	.001	57	view →
HNSC	DFS	Median	IV	0.554	0.813	.006	20	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	16	view →
GBM	OS	Tertile	All	0.257	0.570	.005	7	view →
LSCC	OS	Quartile	All	0.798	0.952	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HS1BP3–PDAC (OS)

Open the PDAC breakdown →