HS1BP3

Across TCGA patient cohorts, HS1BP3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS1BP3-associated genes across cancer lineages are MEK1, Rictor_pT1135, and 4E-BP1. Each is linked with HS1BP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS1BP3-to-partner and partner-to-HS1BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HS1BP3-low versus HS1BP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS1BP3→partner) and Y-score (partner→HS1BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.470	+2.906	.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.109	-3.169	.008	.018	3	2
UCEC	4E-BP1 →	+0.292	+3.489	.007	.002	3	2
UCEC	eEF2 →	+0.417	+2.584	.003	.010	3	1
UCEC	EGFR_pY1068 →	-0.286	-2.415	.004	.003	3	1
UCEC	A-Raf_pS299 →	-0.174	-2.222	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by HS1BP3 expression — UCEC

Explore this box plot interactively →