HS1BP3-IT1

Across TCGA pan-cancer cohorts, HS1BP3-IT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HS1BP3-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HS1BP3-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HS1BP3-IT1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where HS1BP3-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HS1BP3-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.656	<.001	11	view →
KICH	All	III,IV	−1.454	<.001	10	view →
KIRC	Male	All	+0.830	<.001	8	view →
BRCA	All	II,III,IV	−0.583	<.001	6	view →
UCEC	All	All	−0.568	<.001	6	view →
KIRP	All	III,IV	−0.465	.013	6	view →
LUSC	All	All	−0.484	<.001	5	view →
COAD	All	All	+0.374	.004	5	view →
CHOL	All	All	−2.636	<.001	3	view →
LIHC	All	All	−0.565	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HS1BP3-IT1–HNSC

Open the HNSC breakdown →