HROB

Across TCGA pan-cancer cohorts, HROB mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HROB data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HROB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HROB expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where HROB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.230	0.860	.006	19	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.749	.042	1	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.571	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HROB–PDAC (OS)

Open the PDAC breakdown →