HROB

Across TCGA pan-cancer cohorts, HROB RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HROB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HROB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HROB is over-expressed in tumor.

KIRC, LUAD, and KIRP are the cancer types where HROB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HROB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.891	<.001	12	view →
LUAD	Male	III,IV	+2.688	<.001	11	view →
KIRP	All	IV	+2.110	<.001	11	view →
BLCA	Male	III,IV	+1.982	<.001	11	view →
HNSC	Male	IV	+1.790	<.001	11	view →
COAD	Female	III,IV	+1.532	<.001	11	view →
THCA	Male	III,IV	+0.747	<.001	11	view →
STAD	Female	All	+1.641	<.001	9	view →
LIHC	Female	II,III,IV	+1.218	<.001	9	view →
LUSC	Female	II,III,IV	+2.980	<.001	8	view →
UCEC	All	II,III,IV	+2.206	<.001	6	view →
BRCA	All	II,III,IV	+0.556	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HROB–KIRC

Open the KIRC breakdown →