HROB

Across TCGA patient cohorts, HROB protein abundance is significantly associated with the RNA expression of many other genes, with 1,425 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HROB-associated genes across cancer lineages are LYL1, TAF1B, and FZD9. Each is linked with HROB in more than 1 cancer types. Because this analysis shows association rather than direction, both HROB-to-partner and partner-to-HROB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HROB versus LYL1 in LUAD, with a Pearson correlation of -0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HROB→partner) and Y-score (partner→HROB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LYL1 →	-0.560	-1.794	.002	<.001	3	2
LUAD	TAF1B →	-0.626	-1.794	.001	<.001	3	2
BRCA	FZD9 →	+1.745	+0.939	.002	.005	3	2
BRCA	CEROX1 →	+1.410	+0.682	.005	.009	3	2
GBM	SNORA28 →	-0.869	-0.443	.005	.005	3	2
HNSC	QSOX1 →	+1.009	+1.106	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,425 associations by consensus.

HROB vs LYL1 — LUAD

Explore this scatter interactively →