HROB

Across TCGA patient cohorts, HROB mutation is significantly associated with the RNA expression of many other genes, with 1,591 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HROB-associated genes across cancer lineages are L3MBTL2, NF2, and FANCA. Each is linked with HROB in more than 2 cancer types. Because this analysis shows association rather than direction, both HROB-to-partner and partner-to-HROB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by HROB-low versus HROB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HROB→partner) and Y-score (partner→HROB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	L3MBTL2 →	+0.520	+3.472	<.001	.002	3	3
SKCM	NF2 →	+0.597	+3.379	.001	.005	3	3
COAD	FANCA →	+0.706	+3.459	<.001	.005	3	3
COAD	UHRF1 →	+0.808	+3.472	<.001	.002	3	3
UCEC	TRMU →	+0.460	+2.732	<.001	.003	3	3
COAD	MRM3 →	+0.639	+3.352	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,591 associations by consensus.

L3MBTL2 by HROB expression — COAD

Explore this box plot interactively →