HROB

Across TCGA cell cohorts, HROB mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HROB-associated genes across cancer lineages are STH, DCD, and RBMXL3. Each is linked with HROB in more than 1 cancer types. Because this analysis shows association rather than direction, both HROB-to-partner and partner-to-HROB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STH grouped by HROB-low versus HROB-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HROB→partner) and Y-score (partner→HROB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	STH →	+0.076	+4.906	<.001	.006	3	2
LUNG_NSCLC_LUSC	DCD →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	RBMXL3 →	+0.006	+4.643	<.001	.008	3	1
OESOPHAGUS	SPATA31E1 →	+0.166	+4.906	<.001	.006	3	1
SKIN	SLC10A2 →	+0.004	+4.437	<.001	.004	3	1
SKIN	RHOXF2 →	+0.083	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

STH by HROB expression — OESOPHAGUS

Explore this box plot interactively →