HRH4

Across TCGA patient cohorts, HRH4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRH4-associated genes across cancer lineages are Smad4, EGFR_pY1068, and eIF4E. Each is linked with HRH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH4-to-partner and partner-to-HRH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by HRH4-low versus HRH4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH4→partner) and Y-score (partner→HRH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad4 →	+0.181	+3.182	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.263	-3.584	.029	.002	3	1
UCEC	eIF4E →	+0.216	+3.169	.033	.019	2	2
UCEC	ERK2 →	+0.257	+3.169	.005	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.449	.028	.019	3	1
UCEC	Gab2 →	+0.346	+2.459	.044	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Smad4 by HRH4 expression — SKCM

Explore this box plot interactively →