HRH4

Across TCGA cell cohorts, HRH4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,275 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HRH4-associated GO terms across cancer lineages are Lysosomal transport, Regulation of delayed rectifier potassium channel activity, and Regulation of interleukin-6-mediated signaling pathway. Each is linked with HRH4 in more than 5 cancer types. Because this analysis shows association rather than direction, both HRH4-to-partner and partner-to-HRH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal transport grouped by HRH4-low versus HRH4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH4→partner) and Y-score (partner→HRH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Lysosomal transport →	+0.035	+0.043	.005	.001	3	6
BLOOD_Leukemia	Regulation of delayed rectifier potassium channel activity →	-0.336	-0.249	<.001	.003	3	5
BLOOD_Lymphoma	Regulation of interleukin-6-mediated signaling pathway →	+0.104	+0.090	<.001	.001	3	5
PANCREAS	Response to hydrostatic pressure →	+0.078	+0.038	.009	.005	3	5
SOFT_TISSUE	Positive regulation of cell fate commitment →	+0.242	+0.031	<.001	.006	3	5
LARGE_INTESTINE	Cellular response to water stimulus →	+0.078	+0.044	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,275 associations by consensus.

Lysosomal transport by HRH4 expression — SKIN

Explore this box plot interactively →