HRG

Across TCGA patient cohorts, HRG mutation is significantly associated with the RNA expression of many other genes, with 2,232 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRG-associated genes across cancer lineages are TXNL4A, ZFYVE19, and H3P18. Each is linked with HRG in more than 2 cancer types. Because this analysis shows association rather than direction, both HRG-to-partner and partner-to-HRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL4A grouped by HRG-low versus HRG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRG→partner) and Y-score (partner→HRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXNL4A →	+0.319	+1.939	.008	.009	3	3
UCEC	ZFYVE19 →	+0.508	+3.828	<.001	<.001	3	3
UCEC	H3P18 →	+0.299	+1.618	.004	.005	3	3
SKCM	RNU6-1307P →	+0.074	+2.993	<.001	.005	3	3
SKCM	RAB28P1 →	+0.008	+4.173	<.001	.003	3	3
UCEC	EMC9 →	+0.432	+2.775	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,232 associations by consensus.

TXNL4A by HRG expression — UCEC

Explore this box plot interactively →