HRC

Across TCGA patient cohorts, HRC protein abundance is significantly associated with the RNA expression of many other genes, with 10,730 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HRC-associated genes across cancer lineages are MYCT1, KLF2, and MMRN1. Each is linked with HRC in more than 5 cancer types. Because this analysis shows association rather than direction, both HRC-to-partner and partner-to-HRC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HRC versus MYCT1 in CCRCC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRC→partner) and Y-score (partner→HRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYCT1 →	+0.975	+0.580	<.001	<.001	3	5
CCRCC	KLF2 →	+0.912	+0.659	<.001	<.001	3	5
LUAD	MMRN1 →	+1.322	+0.474	<.001	.004	3	5
HNSC	KCNN3 →	+0.909	+1.496	<.001	<.001	3	5
CCRCC	DIPK2B →	+0.820	+0.577	<.001	<.001	3	5
LUAD	RACGAP1 →	-0.871	-0.486	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,730 associations by consensus.

HRC vs MYCT1 — CCRCC

Explore this scatter interactively →