HRC

Across TCGA pan-cancer cohorts, HRC RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HRC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where HRC RNA is repressed in tumor relative to normal tissue. In most cancer types HRC is over-expressed in tumor, although a few such as KIRP and BLCA show the opposite, repressed pattern.

KIRP, BLCA, and LUAD are the cancer types where HRC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HRC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−1.830	<.001	11	view →
BLCA	Male	All	−1.279	<.001	11	view →
LUAD	All	III,IV	−0.764	<.001	11	view →
KICH	Male	II,III,IV	−1.308	<.001	9	view →
HNSC	Male	All	−1.947	.005	7	view →
LUSC	Male	All	−1.161	<.001	7	view →
UCEC	All	All	−1.850	<.001	6	view →
BRCA	All	II,III,IV	−1.007	<.001	6	view →
COAD	All	II,III,IV	−0.298	.002	6	view →
LIHC	All	All	+0.404	.002	5	view →
THCA	All	IV	−1.444	.005	4	view →
KIRC	Female	All	+0.644	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HRC–KIRP

Open the KIRP breakdown →