HRC

Across TCGA cell cohorts, HRC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,449 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HRC-associated GO terms across cancer lineages are Nucleic acid catabolic process, Regulation of chromatin organization, and Regulation of isotype switching to IgE isotypes. Each is linked with HRC in more than 7 cancer types. Because this analysis shows association rather than direction, both HRC-to-partner and partner-to-HRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by HRC-low versus HRC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HRC→partner) and Y-score (partner→HRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.057	+0.122	<.001	.007	3	8
BONE	Regulation of chromatin organization →	+0.082	+0.135	.002	<.001	3	8
LIVER	Regulation of isotype switching to IgE isotypes →	-1.672	-1.428	<.001	.002	3	8
LIVER	Positive regulation of isotype switching to IgE isotypes →	-1.672	-1.428	<.001	.002	3	8
LUNG_SCLC	Fat cell proliferation →	-0.382	-0.209	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.182	+1.407	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,449 associations by consensus.

Nucleic acid catabolic process by HRC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →