HRC

Across TCGA cell cohorts, HRC mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HRC-associated genes across cancer lineages are MMD2, OR13C5, and OR11H1. Each is linked with HRC in more than 1 cancer types. Because this analysis shows association rather than direction, both HRC-to-partner and partner-to-HRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by HRC-low versus HRC-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRC→partner) and Y-score (partner→HRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MMD2 →	+0.063	+5.087	<.001	.004	3	1
URINARY_TRACT	OR13C5 →	+0.760	+5.087	<.001	.004	3	1
OVARY	OR11H1 →	+0.041	+3.700	<.001	.005	3	1
OVARY	TAAR5 →	+0.033	+4.222	<.001	.006	3	1
OVARY	KRTAP5-6 →	+0.171	+3.700	<.001	.008	3	1
OVARY	IFNA17 →	+0.012	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MMD2 by HRC expression — URINARY_TRACT

Explore this box plot interactively →