HR

Across TCGA patient cohorts, HR protein abundance is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HR-associated genes across cancer lineages are MANBAL, RNF128, and SORBS2. Each is linked with HR in more than 1 cancer types. Because this analysis shows association rather than direction, both HR-to-partner and partner-to-HR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HR versus MANBAL in BRCA, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HR→partner) and Y-score (partner→HR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MANBAL →	+0.427	+0.535	.001	.009	3	1
BRCA	RNF128 →	-1.020	-0.637	.006	<.001	3	1
BRCA	SORBS2 →	-2.327	-0.803	.002	.001	3	1
BRCA	U2AF1 →	-0.892	-0.758	.003	.002	3	1
BRCA	TM2D2 →	+0.929	+0.782	<.001	.004	3	1
BRCA	PRR13 →	+0.687	+0.785	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

HR vs MANBAL — BRCA

Explore this scatter interactively →