HR

Across TCGA patient cohorts, HR mutation is significantly associated with the RNA expression of many other genes, with 2,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HR-associated genes across cancer lineages are FAM151B, EIF1AD, and WDHD1. Each is linked with HR in more than 2 cancer types. Because this analysis shows association rather than direction, both HR-to-partner and partner-to-HR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM151B grouped by HR-low versus HR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HR→partner) and Y-score (partner→HR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM151B →	+0.200	+2.076	.006	.004	3	3
UCEC	EIF1AD →	+0.210	+2.332	.007	.003	3	3
SKCM	WDHD1 →	+0.588	+2.341	.005	.003	3	3
UCEC	LINC01128 →	+0.264	+2.162	<.001	.002	3	3
UCEC	CDK11B →	+0.246	+2.110	.007	<.001	3	3
UCEC	ABHD5 →	+0.447	+1.557	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,727 associations by consensus.

FAM151B by HR expression — UCEC

Explore this box plot interactively →