HR

Across TCGA cell cohorts, HR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,491 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HR-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription, elongation, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Mitral valve formation. Each is linked with HR in more than 10 cancer types. Because this analysis shows association rather than direction, both HR-to-partner and partner-to-HR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription, elongation grouped by HR-low versus HR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HR→partner) and Y-score (partner→HR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.106	+2.001	.002	.002	2	11
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.177	+2.545	<.001	.001	3	10
BONE	Mitral valve formation →	+0.952	+1.906	<.001	<.001	3	9
BONE	RNA catabolic process →	+0.063	+2.586	<.001	<.001	3	9
OVARY	Regulation of myoblast fusion →	+0.090	+2.256	<.001	<.001	3	9
OVARY	Negative regulation of myoblast fusion →	+0.110	+1.434	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,491 associations by consensus.

Negative regulation of DNA-templated transcription, elongation by HR expression — BONE

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