HR

Across TCGA cell cohorts, HR mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HR-associated genes across cancer lineages are GJD4, PHOX2B, and LRIT1. Each is linked with HR in more than 2 cancer types. Because this analysis shows association rather than direction, both HR-to-partner and partner-to-HR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD4 grouped by HR-low versus HR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HR→partner) and Y-score (partner→HR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GJD4 →	+0.033	+3.430	<.001	.002	3	3
BLOOD_Leukemia	PHOX2B →	+0.022	+4.687	<.001	<.001	3	2
BLOOD_Leukemia	LRIT1 →	+0.027	+4.099	<.001	<.001	3	2
BLOOD_Leukemia	TMEM89 →	+0.222	+3.584	<.001	.004	3	2
BLOOD_Leukemia	ELOA3DP →	+0.169	+3.007	<.001	.007	3	2
SKIN	CCT8L2 →	+0.043	+4.022	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

GJD4 by HR expression — BLOOD_Leukemia

Explore this box plot interactively →