HPX

Across TCGA patient cohorts, HPX protein abundance is significantly associated with the RNA expression of many other genes, with 14,735 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HPX-associated genes across cancer lineages are ADGRL4, AOC3, and DIPK2B. Each is linked with HPX in more than 8 cancer types. Because this analysis shows association rather than direction, both HPX-to-partner and partner-to-HPX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPX versus ADGRL4 in BRCA, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPX→partner) and Y-score (partner→HPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADGRL4 →	+0.771	+0.620	<.001	<.001	3	9
BRCA	AOC3 →	+1.202	+0.592	<.001	<.001	3	8
OV	DIPK2B →	+0.902	+0.729	<.001	<.001	3	8
BRCA	SHE →	+0.628	+0.595	<.001	<.001	3	8
HNSC	EBF2 →	+0.730	+0.343	<.001	<.001	3	8
HNSC	LINC00702 →	+0.677	+0.271	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,735 associations by consensus.

HPX vs ADGRL4 — BRCA

Explore this scatter interactively →