HPSE2

Across TCGA patient cohorts, HPSE2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,661 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HPSE2-associated genes across cancer lineages are PES1, CRYBB3, and SRRD. Each is linked with HPSE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPSE2-to-partner and partner-to-HPSE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPSE2 versus PES1 in LSCC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE2→partner) and Y-score (partner→HPSE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PES1 →	-0.601	-1.307	<.001	.001	3	1
LSCC	CRYBB3 →	-0.773	-1.180	.005	.002	3	1
LSCC	SRRD →	-0.382	-0.989	<.001	.001	3	1
LSCC	EIF3L →	-0.583	-1.339	<.001	<.001	3	1
LSCC	POLR2F →	-0.442	-1.135	.001	.002	3	1
LSCC	XBP1 →	+0.522	+0.947	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,661 associations by consensus.

HPSE2 vs PES1 — LSCC

Explore this scatter interactively →