HPSE2

Across TCGA pan-cancer cohorts, HPSE2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HPSE2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HPSE2 RNA is repressed in tumor relative to normal tissue. In most cancer types HPSE2 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where HPSE2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPSE2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.902	<.001	12	view →
BLCA	Male	III,IV	−4.514	<.001	11	view →
LUAD	Female	III,IV	−1.608	<.001	11	view →
KIRC	Female	All	−1.273	<.001	11	view →
KIRP	All	All	−0.926	<.001	9	view →
THCA	Female	II,III,IV	+0.803	<.001	9	view →
LUSC	All	III,IV	−1.790	<.001	8	view →
KICH	Male	All	−1.933	<.001	7	view →
BRCA	All	II,III,IV	−2.299	<.001	6	view →
UCEC	All	All	−1.902	<.001	6	view →
HNSC	Female	II,III,IV	−0.360	.010	6	view →
READ	Female	All	−2.316	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HPSE2–COAD

Open the COAD breakdown →