HPSE2

Across TCGA patient cohorts, HPSE2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPSE2-associated genes across cancer lineages are Cyclin-B1, FASN, and Caspase-7-cleavedD198. Each is linked with HPSE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HPSE2-to-partner and partner-to-HPSE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HPSE2-low versus HPSE2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE2→partner) and Y-score (partner→HPSE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.662	+3.178	.013	.010	3	3
COAD	FASN →	+0.698	+3.178	<.001	.010	3	2
COAD	Caspase-7-cleavedD198 →	+1.137	+2.824	.003	.034	3	2
UCEC	4E-BP1 →	+0.310	+2.807	<.001	.002	3	2
UCEC	eIF4E →	+0.177	+1.836	.007	.001	3	2
UCEC	eIF4G →	+0.207	+1.137	.034	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Cyclin-B1 by HPSE2 expression — COAD

Explore this box plot interactively →