HPSE2

Across TCGA cell cohorts, HPSE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,637 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPSE2-associated GO terms across cancer lineages are Regulation of macroautophagy, Regulation of protein kinase activity, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with HPSE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPSE2-to-partner and partner-to-HPSE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by HPSE2-low versus HPSE2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE2→partner) and Y-score (partner→HPSE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of macroautophagy →	+0.028	+1.615	.003	.001	3	5
BLOOD_Leukemia	Regulation of protein kinase activity →	+0.020	+1.494	<.001	<.001	3	5
LARGE_INTESTINE	Regulation of syncytium formation by plasma membrane fusion →	+0.050	+0.019	<.001	.009	3	4
LUNG_NSCLC_LUSC	snRNA metabolic process →	+0.061	+0.038	.001	.006	3	4
LUNG_NSCLC_LUSC	Negative regulation of cell cycle phase transition →	+0.051	+0.032	.008	.008	3	4
LUNG_NSCLC_LUSC	Negative regulation of RNA splicing →	+0.069	+0.027	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,637 associations by consensus.

Regulation of macroautophagy by HPSE2 expression — BLOOD_Leukemia

Explore this box plot interactively →