HPSE2

Across TCGA cell cohorts, HPSE2 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPSE2-associated genes across cancer lineages are GUCA2A, RETNLB, and GCAT. Each is linked with HPSE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPSE2-to-partner and partner-to-HPSE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by HPSE2-low versus HPSE2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE2→partner) and Y-score (partner→HPSE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	2
STOMACH	RETNLB →	+0.528	+3.632	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.286	+3.502	<.001	.001	3	1
LARGE_INTESTINE	SNW1 →	+0.383	+2.451	.004	.009	3	1
LARGE_INTESTINE	TRIP11 →	+0.648	+3.169	<.001	.009	3	1
LARGE_INTESTINE	SNPH →	+0.863	+3.675	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

GUCA2A by HPSE2 expression — BLOOD_Leukemia

Explore this box plot interactively →