HPSE

Across TCGA patient cohorts, HPSE RNA expression is significantly associated with the protein abundance of many other proteins, with 14,467 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPSE-associated proteins across cancer lineages are RASAL3, CCDC88B, and CORO1A. Each is linked with HPSE in more than 6 cancer types. Because this analysis shows association rather than direction, both HPSE-to-partner and partner-to-HPSE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPSE versus RASAL3 in UCEC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE→partner) and Y-score (partner→HPSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RASAL3 →	+0.554	+0.973	<.001	<.001	3	7
COAD	CCDC88B →	+0.836	+1.045	<.001	<.001	3	6
GBM	CORO1A →	+0.577	+0.913	<.001	<.001	3	6
COAD	CRLF3 →	+0.382	+0.861	<.001	<.001	3	6
GBM	CYRIB →	+0.366	+0.875	<.001	<.001	3	6
GBM	DEF6 →	+0.557	+0.943	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,467 associations by consensus.

HPSE vs RASAL3 — UCEC

Explore this scatter interactively →