HPSE

Across TCGA pan-cancer cohorts, HPSE RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HPSE’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where HPSE RNA is repressed in tumor relative to normal tissue. In most cancer types HPSE is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.

UCEC, STAD, and THCA are the cancer types where HPSE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPSE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	III,IV	−1.359	<.001	8	view →
STAD	All	All	+1.127	<.001	8	view →
THCA	Male	All	+0.863	<.001	8	view →
COAD	All	All	−0.728	<.001	7	view →
KIRP	Male	II,III,IV	−0.923	.001	6	view →
BRCA	All	II,III,IV	+0.476	<.001	6	view →
LUAD	All	All	+0.458	<.001	6	view →
LUSC	Male	All	+0.693	<.001	4	view →
CHOL	All	All	+1.371	.001	2	view →
PAAD	Male	All	+0.359	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HPSE–UCEC

Open the UCEC breakdown →