HPSE

Across TCGA patient cohorts, HPSE protein abundance is significantly associated with the RNA expression of many other genes, with 8,444 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HPSE-associated genes across cancer lineages are CCR1, APOBEC3A, and LRRC25. Each is linked with HPSE in more than 4 cancer types. Because this analysis shows association rather than direction, both HPSE-to-partner and partner-to-HPSE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPSE versus CCR1 in BRCA, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE→partner) and Y-score (partner→HPSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCR1 →	+1.106	+0.906	<.001	<.001	3	5
BRCA	APOBEC3A →	+1.710	+0.880	<.001	<.001	3	5
BRCA	LRRC25 →	+0.850	+0.878	.001	<.001	3	5
GBM	NLRC4 →	+0.632	+0.675	<.001	<.001	3	5
BRCA	TYROBP →	+0.952	+1.080	<.001	<.001	3	4
HNSC	WDR35 →	-0.966	-0.588	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,444 associations by consensus.

HPSE vs CCR1 — BRCA

Explore this scatter interactively →