HPSE

Across TCGA cell cohorts, HPSE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,763 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HPSE-associated GO terms across cancer lineages are Positive regulation of cytoplasmic translation, Negative regulation of cell cycle phase transition, and Negative regulation of cell cycle process. Each is linked with HPSE in more than 9 cancer types. Because this analysis shows association rather than direction, both HPSE-to-partner and partner-to-HPSE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic translation grouped by HPSE-low versus HPSE-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPSE→partner) and Y-score (partner→HPSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of cytoplasmic translation →	+0.078	+0.850	.001	<.001	3	10
BREAST	Negative regulation of cell cycle phase transition →	+0.067	+1.955	<.001	<.001	3	10
BREAST	Negative regulation of cell cycle process →	+0.065	+1.522	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Kinin cascade →	+0.969	+1.380	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Plasma kallikrein-kinin cascade →	+0.969	+1.380	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Factor XII activation →	+0.969	+1.380	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,763 associations by consensus.

Positive regulation of cytoplasmic translation by HPSE expression — SKIN

Explore this box plot interactively →