HPS4

Across TCGA pan-cancer cohorts, HPS4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HPS4 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HPS4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HPS4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where HPS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.455	0.789	.010	10	view →
UCEC	DFS	Median	All	0.913	0.777	.031	10	view →
HNSC	OS	Median	IV	0.604	0.890	.012	6	view →
GBM	DFS	Median	All	0.445	0.234	.033	2	view →
PDAC	DFS	Quartile	II,III,IV	0.275	0.504	.026	2	view →
LUAD	OS	Median	II,III,IV	0.784	0.998	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HPS4–CCRCC (DFS)

Open the CCRCC breakdown →