HPS1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HPS1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS1-associated genes across cancer lineages are SMC4, ATAD2, and TMED6. Each is linked with HPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS1-to-partner and partner-to-HPS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS1 versus SMC4 in LSCC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS1→partner) and Y-score (partner→HPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCSMC4 →-0.679-0.238.001<.00132
UCECATAD2 →-0.859-0.368.001.00132
UCECTMED6 →+0.595+0.257.003.00632
LSCCMIS18A →-0.563-0.243.004<.00132
UCECZFYVE28 →+0.562+0.312.006.00132
LSCCGMPS →-0.516-0.201.008.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 11,403 associations by consensus.

HPS1 vs SMC4 — LSCC

Per-sample scatter of HPS1 vs SMC4 in LSCC (Pearson r = -0.35).

Explore this scatter interactively →

Exploration